Use of Bitter Melon in Pancreatic Cancer - Extract from research study by University of Colarado
Pancreatic cancer is one of the most difficult cancers to treat due to
the fact that it is often discovered late, leaving very little time to
treat. Since traditional therapies (chemotherapy, radiation, surgery
etc) were not showing promising results and littler advancement was
being made, researchers have been looking elsewhere to find treatment.
Bitter melon is a fruit that grows abundantly in Asia, Africa and the Caribbean. Traditionally it has been used to treat diabetes and other more mild diseases or illnesses.The fruit and seeds of Bitter Melon are used to make medicine.
Other Common names of Bitter Melon :- African Cucumber, Ampalaya, Balsam Pear, Balsam-Apple, Balsambirne, Balsamine, Balsamo, Bitter Apple, Bitter Cucumber, Bitter Gourd, Bittergurke, Carilla Fruit, Carilla Gourd, Cerasee, Chinli-Chih, Concombre Africain, Courge Amère, Cundeamor, Fructus Mormordicae Grosvenori, Karavella, Kathilla, Karela, Kareli, Kerala, Kuguazi, K'u-Kua, Lai Margose, Margose, Melón Amargo, Melon Amer, Momordica, Momordica charantia, Momordica murcata, Momordique, Paroka, Pepino Montero, Poire Balsamique, Pomme de Merveille, P'u-T'ao, Sorosi, Sushavi, Vegetable insulin, Wild Cucumber.
Bitter melon is used for various stomach and intestinal disorders including gastrointestinal (GI) upset, ulcers, colitis, constipation, and intestinal worms. It is also used for diabetes, kidney stones, fever, a skin condition called psoriasis, and liver disease; to start menstruation; and as supportive treatment for people with HIV/AIDS.
Topically, bitter melon is used for deep skin infections (abscesses) and wounds.
Bitter melon is used as a vegetable in India and other Asian countries and as an ingredient in some kinds of curries.
How does it work for Diabetes ?
Bitter melon contains a chemical that acts like insulin to help reduce blood sugar levels.
How Does it Work in Pancreatic Cancer ?
Bitter Melon Juice anticancer efficacy was analyzed in human pancreatic carcinoma BxPC-3, MiaPaCa-2, AsPC-1 and Capan-2 cells by 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium bromide, cell death enzyme-linked immunosorbent assay and annexin/propidium iodide assays. BMJ effect on apoptosis regulators was assessed by immunoblotting. In vivo BMJ efficacy was evaluated against MiaPaCa-2 tumors in nude mice, and xenograft was analyzed for biomarkers by immunohistochemistry (IHC). Results showed that BMJ (2–5% v/v) decreases cell viability in all four pancreatic carcinoma cell lines by inducing strong apoptotic death. At molecular level, BMJ caused caspases activation, altered expression of Bcl-2 family members and cytochrome-c release into the cytosol. Additionally, BMJ decreased survivin and X-linked inhibitor of apoptosis protein but increased p21, CHOP and phosphorylated mitogen-activated protein kinases (extracellular signal-regulated kinase 1/2 and p38) levels. Importantly, BMJ activated adenosine monophosphate-activated protein kinase (AMPK), a biomarker for cellular energy status, and an AMPK inhibitor (Compound C) reversed BMJ-induced caspase-3 activation suggesting activated AMPK involvement in BMJ-induced apoptosis. In vivo, oral administration of lyophilized BMJ (5mg in 100 µl water/day/mouse) for 6 weeks inhibited MiaPaCa-2 tumor xenograft growth by 60% (P < 0.01) without noticeable toxicity in nude mice. IHC analyses of MiaPaCa-2 xenografts showed that BMJ also inhibits proliferation, induces apoptosis and activates AMPK in vivo. Overall, BMJ exerts strong anticancer efficacy against human pancreatic carcinoma cells, both in vitro and in vivo, suggesting its clinical usefulness.
It was hence concluded that Bitter melon juice activates cellular energy sensor AMP-activated protein kinase causing apoptotic death of human pancreatic carcinoma cells.
Bitter Melon is incorporated in many ayurvedic medicines. One of the medicines C-win Anti Cancer Ayurvedic Tablets have Bitter melon along with Hirak Bhasma, Suvarna Bhasma, Curcumin Longa, Ginger, etc. Majority of these Herbs are anti cancer & hence the medicine has been seen to provide a greater relief to majority of patients.
The dosage of the tablet is 1 BD empty stomach with warm water.
You can search for these tablets at any of your nearest Ayurvedic store or call on +919619777947 for Home delivery.
Bitter melon is a fruit that grows abundantly in Asia, Africa and the Caribbean. Traditionally it has been used to treat diabetes and other more mild diseases or illnesses.The fruit and seeds of Bitter Melon are used to make medicine.
Other Common names of Bitter Melon :- African Cucumber, Ampalaya, Balsam Pear, Balsam-Apple, Balsambirne, Balsamine, Balsamo, Bitter Apple, Bitter Cucumber, Bitter Gourd, Bittergurke, Carilla Fruit, Carilla Gourd, Cerasee, Chinli-Chih, Concombre Africain, Courge Amère, Cundeamor, Fructus Mormordicae Grosvenori, Karavella, Kathilla, Karela, Kareli, Kerala, Kuguazi, K'u-Kua, Lai Margose, Margose, Melón Amargo, Melon Amer, Momordica, Momordica charantia, Momordica murcata, Momordique, Paroka, Pepino Montero, Poire Balsamique, Pomme de Merveille, P'u-T'ao, Sorosi, Sushavi, Vegetable insulin, Wild Cucumber.
Bitter melon is used for various stomach and intestinal disorders including gastrointestinal (GI) upset, ulcers, colitis, constipation, and intestinal worms. It is also used for diabetes, kidney stones, fever, a skin condition called psoriasis, and liver disease; to start menstruation; and as supportive treatment for people with HIV/AIDS.
Topically, bitter melon is used for deep skin infections (abscesses) and wounds.
Bitter melon is used as a vegetable in India and other Asian countries and as an ingredient in some kinds of curries.
How does it work for Diabetes ?
Bitter melon contains a chemical that acts like insulin to help reduce blood sugar levels.
How Does it Work in Pancreatic Cancer ?
Bitter Melon Juice anticancer efficacy was analyzed in human pancreatic carcinoma BxPC-3, MiaPaCa-2, AsPC-1 and Capan-2 cells by 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium bromide, cell death enzyme-linked immunosorbent assay and annexin/propidium iodide assays. BMJ effect on apoptosis regulators was assessed by immunoblotting. In vivo BMJ efficacy was evaluated against MiaPaCa-2 tumors in nude mice, and xenograft was analyzed for biomarkers by immunohistochemistry (IHC). Results showed that BMJ (2–5% v/v) decreases cell viability in all four pancreatic carcinoma cell lines by inducing strong apoptotic death. At molecular level, BMJ caused caspases activation, altered expression of Bcl-2 family members and cytochrome-c release into the cytosol. Additionally, BMJ decreased survivin and X-linked inhibitor of apoptosis protein but increased p21, CHOP and phosphorylated mitogen-activated protein kinases (extracellular signal-regulated kinase 1/2 and p38) levels. Importantly, BMJ activated adenosine monophosphate-activated protein kinase (AMPK), a biomarker for cellular energy status, and an AMPK inhibitor (Compound C) reversed BMJ-induced caspase-3 activation suggesting activated AMPK involvement in BMJ-induced apoptosis. In vivo, oral administration of lyophilized BMJ (5mg in 100 µl water/day/mouse) for 6 weeks inhibited MiaPaCa-2 tumor xenograft growth by 60% (P < 0.01) without noticeable toxicity in nude mice. IHC analyses of MiaPaCa-2 xenografts showed that BMJ also inhibits proliferation, induces apoptosis and activates AMPK in vivo. Overall, BMJ exerts strong anticancer efficacy against human pancreatic carcinoma cells, both in vitro and in vivo, suggesting its clinical usefulness.
It was hence concluded that Bitter melon juice activates cellular energy sensor AMP-activated protein kinase causing apoptotic death of human pancreatic carcinoma cells.
Scientific Evidence
Pancreatic Cancer
Many
cancerous tumors have insulin receptors which move glucose to cancer
cells helping them to grow and divide. Studies have shown that insulin
encourages pancreatic cancer cells to grow in a dose dependant manner,
since bitter melon has been shown to help regulate insulin levels, this
could help prevent pancreatic cancer over the long-term.
The
Colorado University study was led by Dr. Rajesh Agarwal. They
examined effects of bitter melon on 4 different lines of pancreatic
cancer cells (in vitro) and in mice. For the in vivo studies, mice were
injected with pancreatic tumor cells and were randomly divided into one
of two groups. One group of mice received water, which was the control
group, and the other group was given bitter melon juice for six weeks.
Researchers
studied the tumors at the end of the study and results showed that
bitter melon juice not only inhibited cancer cell proliferation but also
induced apoptosis (programmed cell death). Compared to the control,
tumor growth was inhibited by 60% in the treatment group and there were
no signs of toxicity or negative effects on the body. With toxicity and
negative effects being a huge role in traditional mainstream treatments,
this was positive to see.
Diabetes
A
number of clinical studies have been conducted to evaluate the efficacy
of bitter melon for treating diabetes. Since it is believed that
diabetes is a precursor for pancreatic cancer, researchers felt bitter
melon could treat diabetes as well after seeing pancreatic cancer
results.
In 2011, results of a four week long clinical trial were published in the Journal of Ethnopharmacology that showed modest hypoglycemic effects and significant fructosamine management for those taking 2000mg/day of bitter melon.
As
published by the study: "Bitter melon had a modest hypoglycemic effect
and significantly reduced fructosamine levels from baseline among
patients with type 2 diabetes who received 2,000 mg/day. However, the
hypoglycemic effect of bitter melon was less than metformin 1,000
mg/day.
Another study published in 2008 in the international journal Chemistry and Biology
indicated that compounds in bitter melon improved glycemic control,
helped cells uptake glucose and improved overall glucose tolerance. This
study was done in mice and led to promising advancements in treating
diabetes and obesity with bitter melon.
How To Use Bitter Melon ?Bitter Melon is incorporated in many ayurvedic medicines. One of the medicines C-win Anti Cancer Ayurvedic Tablets have Bitter melon along with Hirak Bhasma, Suvarna Bhasma, Curcumin Longa, Ginger, etc. Majority of these Herbs are anti cancer & hence the medicine has been seen to provide a greater relief to majority of patients.
The dosage of the tablet is 1 BD empty stomach with warm water.
You can search for these tablets at any of your nearest Ayurvedic store or call on +919619777947 for Home delivery.
Labels: anti cancer., ayurvedic treatment, bitter melon, home delivery, pancreatic cancer